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Abstract

Statin can moderately reduce blood pressure in patients with hypertension, the suggested mechanisms are enhanced endothelial NO generation, anti-inflammatory and antioxidant effect. Previous studies also suggested involvement of angiotensin receptor blockade in statin mediated hypotension. The current aimed to examine the effect of acute rosuvastatin on aldosterone levels in relation to blood pressure reduction with special concern to male and female variation. Rosuvastatin was prescribed for 11 women and 15 men hypertensive patients with dyslipidemia. Evaluation of aldosterone, blood pressure, lipid profile, BMI, Na+, and K+ were conducted both before and after six weeks treatment. The pulse pressure (PP) and mean arterial pressure (MAP) was calculated to determine the vascular compliance and hemodynamic load. To evaluate the association factors, total male results were evaluated against female results using statistical t-test. A significant improvement in cholesterol and triglycerides was observed in all patients. SBP and aldosterone levels were significantly reduced. While Na⁺ levels was slightly reduced, no significant change was observed with K⁺ levels. Male patients showed significantly more reduction in aldosterone than female, suggesting a sex-specific differences. However, rosuvastatin lowered both pulse pressure and mean arterial pressure to a similar extent in both men and women. The results suggest that rosuvastatin have a wide-ranging effect on cardiovascular status. Sex variation might be important finding and deserve further research.

Keywords: Rosuvastatin, Aldosterone, Blood pressure, Total cholesterol, Gender differences

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