Co-surfactant effect of polyethylene glycol 400 on microemulsion using BCS class II model drug
Abstract
Microemulsions are an intriguing method for delivering poorly soluble drugs, protecting labile drugs, controlling drug release, and increasing drug bioavailability. They can be given topically, orally, or intravenously, and use polyethylene glycol (PEG-400) as a co-surfactant to improve the solubility and stability of biological classification system (BCS) class II drugs. The goal of this research is to develop and test an oil-in-water (O/W) microemulsion-based formulation to improve the solubility and possibly the stability of a hydrophobic medication (carvedilol) by using natural oil and PEG 400 as a co-surfactant. oil in water microemulsion was formulated using the water titration method. pH, particle size, zeta potential, and thermodynamic stability studies were carried out for optimization, followed by in vitro release experiments. Based on component solubility studies and pseudo-ternary phase diagrams, a 1:1 ratio of Tween80 to PEG400 (Smix) was chosen for the final microemulsion preparation. The optimized ME4 formula selected contains 10% oil, 42% Smix, and 48% water. The average globule size was found to be 58 nm, the pH was 6.95, the zeta potential was 28mV, and the percent transmittance was 97.1 percent. The thermodynamic stability study data shows better stability of the final formulation. The solubilization effect of the drug was enhanced by prepared ME formulation and hence confirms the utility of the ME system as a vehicle for better delivery of (BCS) class II.
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