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Abstract

Laparoscopic colorectal surgery is increasingly common, but post-operative pain management remains a major challenge, especially with the use of multiple medications that pose a risk of interaction. This study aims to evaluate the use of analgesics and the rate of clinically significant drug interactions in patients after laparoscopic colorectal surgery. A retrospective cross-sectional study of patient records of laparoscopic colorectal surgery was conducted at Cho Ray Hospital from January to December 2024. Three datasets were used to identify drug interactions. The study used the T-test and Spearman correlation to identify factors affecting drug interactions. Paracetamol and tramadol were the two most commonly used analgesics. The most common drug interactions were dexamethasone-rocuronium (82.4%) and palonosetron-tramadol (30.6%). Patients taking multiple medications had a significantly increased risk of drug interactions (P = 0.03). The number of drug interactions was correlated with the length of hospital stay (r = 0.127; P = 0.004), the number of medications used (r = 0.255; P < 0.001), and the pre- and post-operative pain levels (VAS). This study recommends that careful monitoring and benefit-risk consideration of drug combinations, especially opioids and NSAIDs, are essential to optimize post-operative management of laparoscopic colorectal surgery.‎

Keywords: Cho Ray, Drug interaction, Hospital, Laparoscopic colorectal surgery

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