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Abstract

The interplay between vitamin D (VD) and thyroid function is crucial, especially in pediatrics. Vitamin D deficiency (VDD) can significantly impact thyroid-stimulating hormone (TSH) levels, leading to potential health consequences. This study explores the essential role of VD in regulating thyroid function in children and highlights the clinical implications of VDD on pediatric thyroid health. A cross-sectional study was conducted on 102 children aged 3-18, selected from 2,503 patients referred to an endocrinology clinic. Participants were chosen based on specific inclusion criteria, excluding those with autoimmune thyroid disorders or recent medication use that could interfere with thyroid function. Data on demographic characteristics, thyroid function tests, and VD levels were collected. Statistical analysis was performed using binary logistic regression in IBM SPSS 24. The study population demonstrated significant VDD prevalence, with 63.7% of individuals falling below the recommended level. The mean VD level was found to be 27.66 ng/ml (standard deviation: 13.17 ng/ml). A significant positive correlation was observed between TSH levels and the odds of VDD. For each unit increase in TSH (mIU/L), the odds of deficiency increased by 70% (OR=1.70, CI 95%:1.19-2.43, p=0.003). However, no statistically significant associations were found between VDD and other demographic factors. This study demonstrates a significant positive correlation between VD status and TSH levels in pediatric patients with non-autoimmune hypothyroidism. The findings suggest that VDD may contribute to elevated TSH levels. Therefore, addressing VDD through supplementation may be a valuable adjunct therapy in the management of non-autoimmune hypothyroidism.