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Abstract

In young children, rotavirus is a major cause of severe gastroenteritis.  Vitamin D (calciferol) may affect the course of gastroenteritis and is essential for gut health and immunological control. To evaluate how vitamin D affects inflammation and clinical results in kids with rotavirus gastroenteritis. A prospective, non-randomized study was conducted at Al-Kadhimiya Pediatric Hospital on 60 children under 5 years with vitamin D deficiency and confirmed rotavirus infection. Participants were divided into two groups: Group II received standard treatment plus a single dosage of vitamin D, whereas Group I (control) received regular treatment. Serum vitamin D levels were assessed both at baseline and seven days later. Clinical outcomes and laboratory parameters were assessed on days 1, 4, and 7. Data were analyzed using SPSS v24. Demographic, clinical, and baseline laboratory parameters were comparable between groups. Following intervention, Group II showed significant improvements in temperature and dehydration (P < 0.001), while the control group showed no change. Both groups exhibited time-dependent changes in laboratory markers (CRP, MPV, NLR, PLR) (P < 0.05), with the vitamin D group showing more pronounced improvements (P < 0.001). Vitamin D supplementation in children with rotavirus infection significantly improved clinical outcomes and inflammatory markers, highlighting its potential as an adjunct therapy in pediatric rotavirus gastroenteritis‎.

Keywords: Clinical outcomes, Gastroenteritis, Pediatrics, Rotavirus, Vitamin D

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