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Vadim Albertovich Melkumyan^*✉ , Dzhamilya Abdulvagabovna Kurbanova , Rusalina Serazhutdinovna Magomedgadzhieva , Masis Vaagovich Khidiryan , Stanislav Andreevich Eremin , Vladimir Sergeevich Stepanenko , Amina Alhazurovna Dzhankaeva , Aida Mikhailovna Tanasheva

1. Department of Therapy, Faculty of Pediatrics, Stavropol State Medical University, Stavropol, Russia.
2. Department of Therapy, Faculty of Medicine, Russian University of Medicine, Moscow, Russia.

3. Department of Therapy, Faculty of Medicine, Saratov State Medical University named after V.I. Razumovsky, Saratov, Russia.

Abstract

The article presents the results of studying the effect of a complex of zinc oxide nanoparticles on the reparative regeneration of an experimental wound. The analysis of data from planimetric studies (changes in the area of the wound in dynamics, the rate of wound healing, the daily change in the area of the wound) showed a high wound healing activity of the drug, statistically significantly superior to the indicators in the comparison group. Zinc oxide nanoparticles, in addition to regenerating, have an antimicrobial effect and prevent secondary contamination of the wound, which also contributes to full-fledged reparative regeneration. It has been proven that topical application of the drug in animals with experimental conditionally aseptic wounds provides pronounced regenerating and antibacterial effects. This drug can be used to treat skin and soft tissue injuries of various etiologies. The use of the drug for local wound treatment at all stages of complex treatment will reduce the duration of systemic antimicrobial therapy, avoid the development of side effects, significantly reduce the cost of expensive antibacterial drugs, and avoid the formation of resistance of microflora to the systemic antibiotics used.

Keywords: Nanoparticles, Zinc, Rats, Regeneration, Wound-healing activity

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