Views: 123 Downloads: 42

Abstract

Spindle cell lesions of the salivary glands (SGSCLs) include a broad range of conditions, from high-grade malignancies to benign reactive alterations. Some epithelial and myoepithelial lesions in the salivary glands may take on spindle forms, although spindle cell proliferations are often associated with mesenchymal origin. Diagnostic challenges may result from a wide range of potential differential diagnoses and the substantial clinicopathological feature overlap of SGSCLs. However, it is crucial to establish precise diagnoses to provide the proper clinical care for any specific SGSCLs. Evaluation of growth patterns, cytologic atypia, and component cell border traits are crucial. Immunohistochemistry (IHC) and other ancillary tests are beneficial in situations with complex morphology. This study focuses on the histological characteristics and alternative diagnosis of typical SGSCLs that can broadly be categorized into three major groups: 1. non-neoplastic lesions; 2. benign lesions; 3. malignant lesions. Each category includes a distinct table of differential diagnosis and a panel of IHC markers and molecular tests‎.