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Analgesic activity of Cuscuta campestris Yuncker a parasitic plant grown on Nerium indicum Mill


Ghule R.S , Venkatnarayanan R , Thakare S.P , Jain H , Ghule P.R

Abstract

Cuscuta campestris is the most widespread species in the genus Cuscuta belonging to family Convolvulaceae throughout the World. Cuscuta campestris possess to have anthelmintic activity. The ethanol extract of plant also proved to have Analgesic, antipyretic and anti- inflammatory activity (Azza, et al., 1996) on different host. The dried methanol extract (CC ME) of the whole plant of Cuscuta campestris Yuncker was studied for its analgesic activity grown on Nerium indicum (Apocyanaceae). Analgesic activity was carried out using animal models i.e. Acetic acid Induced Writhing Test (Chemical Stimulation) and Heat conduction method in comparison with Diclofenac sodium as reference standard (Positive control). The CC ME was given in doses of 100, 200 and 400 mg/kg body weight in which dose 400 mg/kg given significant results in comparison with reference standard Diclofenac sodium. The study may conclude that some chemical entities transferred from host Nerium indicum to the parasite Cuscuta campestris are responsible for analgesia.




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