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Abstract

Luc vi, a traditional oriental medicine, is widely recognized for its therapeutic benefits. In capsule form, Luc vi ensures consistent quality and ease of use. However, the production process often leads to challenges such as powder leakage from the capsules, impacting product quality. This study explores the use of paraffin oil treatment to mitigate powder spillage in Luc vi capsules without compromising their quality. Luc vi capsules were prepared using a standard formula and process. Three batches (I1, I2, I3) were assessed for powder-to-granule ratios, quality parameters, and powder leakage. Capsules were treated with paraffin oil in various ratios and seep times to determine optimal conditions. The impact of paraffin oil on capsule quality was evaluated using standard tests for mass uniformity, moisture content, disintegration time, qualitative and quantitative analyses, and powder leakage assessment through a capsule abrasion tester. The optimal treatment was identified as 2 g of paraffin oil per 1 kg of Luc vi capsules with a 3-minute seep time. Post-treatment, capsules (batches II1, II2, II3) showed no powder spillage during testing. All quality standards, including mass uniformity (480 ± 7.5%), moisture content (13-16%), and disintegration time (< 30 minutes), were met. The qualitative and quantitative properties of the capsules remained unchanged after treatment. The application of paraffin oil effectively prevents powder leakage from Luc vi capsules without altering their quality. This simple, scalable method can be applied to other capsule formulations, offering a practical solution to enhance product integrity during production and distribution‎.

Keywords: Capsule quality, Herbal medicine, Luc vi capsules, Manufacturing optimization, Paraffin oil, Powder leakage

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