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The impact of increased body weight on left ventricular diastolic function

Nebaa Raheem Wahab, Mohammed N. Al-dujaili‎, ‎‏ ‏Hassan Ali Hassan AL-Khirsani, Abdullah Abass ‎Mohammed‎‎


Background: Diastolic dysfunction is a problem, due to an impairment in the filling properties of the left ventricle (LV), indicating future heart failure. In obese patients, this problem is a prevalent cause of heart failure in which the systolic function is maintained. Aim of the study: This study was conducted to evaluate the independent effect of increased body weight with different degrees on LV diastolic function. Patients and methods: A retrospective cohort study was done at Al-Sader Medical City in Al Najaf City, Echocardiographic Department during the period from March 2018 to March 2019. 120 patients (age: 61.59 ± 13.9 years) were chosen and LV diastolic function, body mass index (BMI), and waist circumference (WC) were assessed. The patients were divided into 3 groups based on their body mass index (kg/m2): [obese < (29.9); overweight, (25–29.9); normal, (18.5–24.9)]. Peaks late (A) and early (E) transmitral velocities and also peak early diastolic mitral annulus velocity (E′) were measured. Data analysis and management were done by using the SPSS software version 24, 2013. Results: Diastolic dysfunction in the obese/overweight groups was considerably higher than the group with normal BMI. By analyzing the multivariate regression, BMI, and other characteristics, the independent and direct effect of BMI on diastolic function was demonstrated [OR: 2.65; confidence interval (CI): 1.46–5.76; P = 0.007]. Conclusion: Obesity and overweight have a negative independent effect on diastolic function‎.

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