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Abstract

This study identifies prognostic factors for premature mortality in patients with acute ischemic stroke. As a retrospective observational study, it was based on hospital information on patients with acute ischemic stroke referred to Golestan Ahvaz Hospital from February 2022 to the end of July 2023. Premature mortality was recorded in the first 14 days after stroke. It used a multivariable logistic regression model to identify factors of early death in patients.

619 acute ischemic stroke patients participated in this study (mean age 66.01 ± 13.86 years, 47.33% female). The frequency of premature death after stroke was 7.75% (95% CI: 5.31 - 9.83%). High severity of stroke (OR: 12.24; P<0.0001), old age (OR: 2.86; P=0.001), mRS score >0 (OR: 5.68; P=0.0001), presence of AF (OR: 9.35; P<0.0001), ischemic heart disease (OR: 4.65; P=0.0001), cerebrovascular disease (OR: 2.06; P=0.016), level of consciousness (OR: 1.98; P=0.030), and high white blood cell count at hospital admission (OR: 2.11; P=0.002) are independently associated with increased risk of premature death. In contrast, antiplatelet therapy (P=0.001) and thrombolytic therapy (P<0.0001) were associated with a decrease in mortality. Likewise, hypertension, heart failure, use of statins, and accompanying initial symptoms with seizures were associated with premature death only in univariate analysis.

Acute ischemic stroke was associated with a high mortality rate. The risk factors for premature mortality were similar to the results and evidence reported in other articles. Therefore, this higher mortality is avoidable with early diagnosis and adequate management‎.

Keywords: Predictive factors, Risk factor, Premature death, Ischemic stroke

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