Multiorgan pathological findings of severe COVID-19 in deceased patients: a post-mortem study in the Indonesian population ‎

Isnin Anang Marhana; Bambang Pujo Semedi; Ummi Maimunah; Achmad Lefi; Priangga Adi Wiratama; Etty Hary Kusumastuti; Edy Suyanto; Jilientasia Godrace Lilihata; Adhitri Anggoro; Lalu Galih Pratama Rinjani; Supriadi Supriadi; Alfian Nur Rosyid; Dwi Wahyu Indrawanto; Dyah Fauziah; Anny Setijo Rahaju; Nila Kurniasari; Alphania Rahniayu; Grace Ariani; Gilang Muhammad Setyo Nugroho; I Komang Rusgi Yandi; Ricardo Adrian Nugraha; Stephanie Natasha Djuanda; Andro Pramana Witarto

doi:10.51847/bj1NCawFac

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Multiorgan pathological findings of severe COVID-19 in deceased patients: a post-mortem study in the Indonesian population

Isnin Anang Marhana^*✉ , Bambang Pujo Semedi , Ummi Maimunah , Achmad Lefi , Priangga Adi Wiratama , Etty Hary Kusumastuti , Edy Suyanto , Jilientasia Godrace Lilihata , Adhitri Anggoro , Lalu Galih Pratama Rinjani , Supriadi Supriadi , Alfian Nur Rosyid , Dwi Wahyu Indrawanto , Dyah Fauziah , Anny Setijo Rahaju , Nila Kurniasari , Alphania Rahniayu , Grace Ariani , Gilang Muhammad Setyo Nugroho , I Komang Rusgi Yandi , Ricardo Adrian Nugraha , Stephanie Natasha Djuanda , Andro Pramana Witarto

Abstract

Since the WHO declared the COVID-19 epidemic on March 11, 2020, there has been a notable increase in morbidity and death on a global scale. Despite the growing number of cases, limited data exists on the pathological changes in deceased COVID-19 patients, particularly concerning the lungs, heart, and liver. This study aims to describe the histopathological results in the lungs, heart, and Indonesian COVID-19 patients' livers that have died, providing insights into the multiorgan impact of severe SARS-CoV-2 infection. A post-mortem study was conducted on 41 COVID-19 patients treated in a special isolation ward at Dr. Soetomo General Hospital, Surabaya, from July 1, 2020, to December 31, 2020. The heart, liver, and lungs were biopsied using core needles. Histopathological examinations were carried out, and findings were documented and analyzed. The study included 30 males (73.17%) and 11 females, with a mean age of 48.66 ± 12.93 years. In the lungs, the most common findings were interstitial and/or intra-alveolar inflammatory infiltrate (97.56%) and peri- or intravascular inflammatory infiltrate (87.80%). The liver exhibited mild to moderate lobular inflammation (87.80%) and portal inflammation (75.61%). The heart showed interstitial edema (95.12%) and mild myocardial hypertrophy (80.49%). This study revealed significant histopathological abnormalities in the lungs, liver, and heart of deceased COVID-19 patients, highlighting the disease's multiorgan impact. The findings underscore the need for careful monitoring of these organs in severe COVID-19 cases to stop further clinical decline.

Keywords: COVID-19, SARS-CoV-2, Lung, Heart, Liver, Pathology

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Marhana IA, Semedi BP, Maimunah U, Lefi A, Wiratama PA, Kusumastuti EH, et al. Multiorgan pathological findings of severe COVID-19 in deceased patients: a post-mortem study in the Indonesian population. J Adv Pharm Educ Res. 2025;15(3):16-27. https://doi.org/10.51847/bj1NCawFac

APA

Marhana, I. A., Semedi, B. P., Maimunah, U., Lefi, A., Wiratama, P. A., Kusumastuti, E. H., Suyanto, E., Lilihata, J. G., Anggoro, A., Rinjani, L. G. P., et al. (2025). Multiorgan pathological findings of severe COVID-19 in deceased patients: a post-mortem study in the Indonesian population. Journal of Advanced Pharmacy Education and Research, 15(3), 16-27. https://doi.org/10.51847/bj1NCawFac