TY  - JOUR
T1  - Multiorgan pathological findings of severe COVID-19 in deceased patients: a post-mortem study in the Indonesian population ‎
A1  - Isnin Anang Marhana
A1  - Bambang Pujo Semedi
A1  - Ummi Maimunah
A1  - Achmad Lefi
A1  - Priangga Adi Wiratama
A1  - Etty Hary Kusumastuti
A1  - Edy Suyanto
A1  - Jilientasia Godrace Lilihata
A1  - Adhitri Anggoro
A1  - Lalu Galih Pratama Rinjani
A1  - Supriadi Supriadi
A1  - Alfian Nur Rosyid
A1  - Dwi Wahyu Indrawanto
A1  - Dyah Fauziah
A1  - Anny Setijo Rahaju
A1  - Nila Kurniasari
A1  - Alphania Rahniayu
A1  - Grace Ariani
A1  - Gilang Muhammad Setyo Nugroho
A1  - I Komang Rusgi Yandi
A1  - Ricardo Adrian Nugraha
A1  - Stephanie Natasha Djuanda
A1  - Andro Pramana Witarto
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2025
VL  - 15
IS  - 3
DO  - 10.51847/bj1NCawFac
SP  - 16
EP  - 27
N2  - Since the WHO declared the COVID-19 epidemic on March 11, 2020, there has been a notable increase in morbidity and death on a global scale. Despite the growing number of cases, limited data exists on the pathological changes in deceased COVID-19 patients, particularly concerning the lungs, heart, and liver. This study aims to describe the histopathological results in the lungs, heart, and Indonesian COVID-19 patients' livers that have died, providing insights into the multiorgan impact of severe SARS-CoV-2 infection. A post-mortem study was conducted on 41 COVID-19 patients treated in a special isolation ward at Dr. Soetomo General Hospital, Surabaya, from July 1, 2020, to December 31, 2020. The heart, liver, and lungs were biopsied using core needles. Histopathological examinations were carried out, and findings were documented and analyzed. The study included 30 males (73.17%) and 11 females, with a mean age of 48.66 ± 12.93 years. In the lungs, the most common findings were interstitial and/or intra-alveolar inflammatory infiltrate (97.56%) and peri- or intravascular inflammatory infiltrate (87.80%). The liver exhibited mild to moderate lobular inflammation (87.80%) and portal inflammation (75.61%). The heart showed interstitial edema (95.12%) and mild myocardial hypertrophy (80.49%). This study revealed significant histopathological abnormalities in the lungs, liver, and heart of deceased COVID-19 patients, highlighting the disease's multiorgan impact. The findings underscore the need for careful monitoring of these organs in severe COVID-19 cases to stop further clinical decline.
UR  - https://japer.in/article/multiorgan-pathological-findings-of-severe-covid-19-in-deceased-patients-a-post-mortem-study-in-the-ijdynsffuj1fpr4
ER  -