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Leila Nurgamidovna Zairkhanova , Anna Sergeevna Eremina , Rasul Ruslanovich Burkhanov , Mata Magomedovna Bersanova , Susanna Zaurkanovna Agerzhanokova , Fatima Almanovna Muskhadzhieva , Asyat Isaevna Ataeva , Viktor Viktorovich Esyunin^*✉

1. Department of Therapy, Faculty of Medicine, Dagestan State Medical University, Makhachkala, Republic of Dagestan, Russia.
2. Department of Therapy, Faculty of Medicine, Stavropol State Medical University, Stavropol, Russia.
3. Department of Therapy, Faculty of Medicine, Russian University of Medicine, Moscow, Russia.

4. Department of Therapy, Faculty of Medicine, Medical Institute, Chechen State University named after A.A. Kadyrov, Grozny, Republic of Chechnya, Russia.

5. Department of Therapy, Faculty of Pediatrics, Medical Institute, Chechen State University named after A.A. Kadyrov, Grozny, Republic of Chechnya, Russia. 

6. Department of Therapy, Faculty of Pediatrics, Stavropol State Medical University, Stavropol, Russia.

Abstract

Tuberculosis lesion of the upper respiratory tract in most cases is a secondary disease and develops as a result of the introduction of a specific pathogen in patients suffering from pulmonary tuberculosis. Against the background of the deterioration of the general epidemiological situation of tuberculosis, its course has changed in the direction of aggravation of the process and an increase in diseases of extrapulmonary tuberculosis. It is known that silver nanoparticles restore the sensitivity of drug-resistant strains of tuberculosis microbacteria to chemotherapy drugs, and their growth is suppressed. The purpose of the study is to evaluate the effectiveness of the use of silver—containing drugs for the treatment of patients with tuberculosis of the upper respiratory tract. As a result of the study, it was found that silver nanoparticles demonstrate anti-tuberculosis activity. At the same time, the dose-dependent nature of the suppressive activity of nanoparticles was established. Argitos at a concentration of 3.3% showed higher therapeutic activity in the treatment of laryngeal tuberculosis compared with standard anti-tuberculosis drugs.

Keywords: Tuberculosis, Extrapulmonary tuberculosis, Upper respiratory tract, Argitos, Protargol, Silver nanoparticles

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