Enhancement of lcariin aphrodisiac effect by self nano emulsifying drug delivery system (SNEDDS) method
Abstract
The epimedium plant (Epimedium brevicornum Maxim) has activity as an aphrodisiac derived from a flavonoid compound, namely icariin. Icariin has low solubility and bioavailability. The utilization of icariin using the SNEDDS (Self Nanoemulsifying Drug Delivery System) method is expected to increase the solubility and bioavailability of icariin. This study aims to determine the optimum formula, characteristics, physical properties, and aphrodisiac activity of SNEDDS icariin. The optimum formula used is tween 80 (75%): PEG 400 (12.5%) and cucut fish oil (12.5%). The characteristics of SNEDDS icariin obtained were droplet size with an average of 15.63±0.058 nm, PI 0.144±0.062, zeta potential -22.67±2.06 mV, emulsification time 12.30 seconds, and transmittance 97.2%. The physical test of SNEDDS icariin produced in the form of a clear preparation in yellow color, pH 6.52, the viscosity of 120 cps, as well as the SNEDDS icariin dissolution in aqueous media in the 60th minute was 75.40% colluded. SNEDDS icariin dose 50 mg/KgBW has a better aphrodisiac effect than pure icariin 100 mg/kgBW.
Keywords: Aphrodisiac, Epimedium, Icariin, SNEDDS
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