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Evaluation of the neuroprotective effect of root and leaf extracts of Chlorophytum comosum


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Abstract

The aim of this study was a comparative study of the neuroprotective efficacy of root and leaf extracts of Chlorophytum comosum, as well as their combined use in glutamate excitotoxicity in a culture of rat cerebellar neurons. The effect of Chlorophytum comosum extracts on glutamate excitotoxicity was studied on 7–8 day old cultures of cerebellar neurons obtained from 7-9 day old rats by enzyme mechanical dissociation. We found that the addition of extracts of Chlorophytum comosum to the culture medium in the post-glutamate period led to a significant reduction in the death of cerebellar neurons in culture. The percentage of surviving neurons, when Chlorophytum comosum was introduced at a concentration of 60 μg/mL, ranged from 32.7 to 36.5%, and at a concentration of 90 μg/mL, from 37.8 to 42.4%. As a result of the experiment, it was concluded that root and leaf extracts of Chlorophytum comosum have a pronounced and almost equal neuroprotective effect in the case of glutamate excitotoxicity.


How to cite this article:
Vancouver
Yagubova EY, Gusenova GT, Zubiyeva FV, Berezhnaya VV, Pulatova KM, Tomboidi KK, et al. Evaluation of the neuroprotective effect of root and leaf extracts of Chlorophytum comosum. J Adv Pharm Educ Res. 2023;13(3):52-5. https://doi.org/10.51847/W5wvQzvguf
APA
Yagubova, E. Y., Gusenova, G. T., Zubiyeva, F. V., Berezhnaya, V. V., Pulatova, K. M., Tomboidi, K. K., Gasarova, A. R., & Gereykhanova, E. M. (2023). Evaluation of the neuroprotective effect of root and leaf extracts of Chlorophytum comosum. Journal of Advanced Pharmacy Education and Research, 13(3), 52-55. https://doi.org/10.51847/W5wvQzvguf
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