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Elvira Yasharovna Yagubova , Gabidat Teymurovna Gusenova , Fatima Vakhayevna Zubiyeva , Valeriya Vitalevna Berezhnaya , Karina Magomednasirovna Pulatova , Konstantin Khadisovich Tomboidi , Aminat Ruslanovna Gasarova , Elmira Mirzemetovna Gereykhanova

Abstract

The aim of this study was a comparative study of the neuroprotective efficacy of root and leaf extracts of Chlorophytum comosum, as well as their combined use in glutamate excitotoxicity in a culture of rat cerebellar neurons. The effect of Chlorophytum comosum extracts on glutamate excitotoxicity was studied on 7–8 day old cultures of cerebellar neurons obtained from 7-9 day old rats by enzyme mechanical dissociation. We found that the addition of extracts of Chlorophytum comosum to the culture medium in the post-glutamate period led to a significant reduction in the death of cerebellar neurons in culture. The percentage of surviving neurons, when Chlorophytum comosum was introduced at a concentration of 60 μg/mL, ranged from 32.7 to 36.5%, and at a concentration of 90 μg/mL, from 37.8 to 42.4%. As a result of the experiment, it was concluded that root and leaf extracts of Chlorophytum comosum have a pronounced and almost equal neuroprotective effect in the case of glutamate excitotoxicity‎.

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