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Elvira Yasharovna Yagubova, Gabidat Teymurovna Gusenova, Fatima Vakhayevna Zubiyeva, Valeriya Vitalevna Berezhnaya, Karina Magomednasirovna Pulatova, Konstantin Khadisovich Tomboidi, Aminat Ruslanovna Gasarova, Elmira Mirzemetovna Gereykhanova

Abstract

The aim of this study was a comparative study of the neuroprotective efficacy of root and leaf extracts of Chlorophytum comosum, as well as their combined use in glutamate excitotoxicity in a culture of rat cerebellar neurons. The effect of Chlorophytum comosum extracts on glutamate excitotoxicity was studied on 7–8 day old cultures of cerebellar neurons obtained from 7-9 day old rats by enzyme mechanical dissociation. We found that the addition of extracts of Chlorophytum comosum to the culture medium in the post-glutamate period led to a significant reduction in the death of cerebellar neurons in culture. The percentage of surviving neurons, when Chlorophytum comosum was introduced at a concentration of 60 μg/mL, ranged from 32.7 to 36.5%, and at a concentration of 90 μg/mL, from 37.8 to 42.4%. As a result of the experiment, it was concluded that root and leaf extracts of Chlorophytum comosum have a pronounced and almost equal neuroprotective effect in the case of glutamate excitotoxicity‎.

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