Can liver enzyme profile be a predictor of NAFLD in type-2 diabetes mellitus (T2DM) patients?
Abstract
Population-based studies reported that the prevalence of NAFLD in T2DM patients, ranging from 30% - 70%. This study aims to determine differences in liver enzyme profiles in NAFLD patients with and without DM and to make elevated liver enzyme levels a predictor or early screening for NAFLD in T2DM patients. This research is an observational analytic study with a cross sectional approach. Research data collection was carried out in October 2022 at Tugurejo Hospital, Semarang, Indonesia. The research was conducted on the medical records of patients diagnosed with NAFLD from 2020-2021 using the total sampling method. In addition to liver enzyme levels, confounding variables were also taken which are also risk factors for NAFLD, including: age, sex, BMI, lipid profile and blood sugar levels. Prognostic factors were analyzed by bivariate analysis test and multivariate analysis using logistic regression analysis to obtain relative risk values (RR). The results showed that AST (p, OR, CI95% = 0.216, 0.998, (0.995-1.001)) and ALT (p, OR, CI95% = 0.870, 1.000, (0.994-1.005)). are not significant as a predictor of NAFLD in T2DM patients. Other variables that were studied showed that Body Mass Index (p, OR, CI95% = 0.023, 0.874, (0.779-0.982)) and triglyceride levels ((p, OR, CI95% = 0.006, 0.992, (0.986-0.998)) can be used as a predictor of NAFLD in T2DM patients.
Keywords: NAFLD, NAFLD predictor, T2DM, Transaminase enzyme, Liver enzyme
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