Predictors of long-term shortness of breath in COVID-19: A prospective study

Abdimomunova Begimai Toktobolotovna; Kutmanova Ainura Zarylbekovna; Dautov Timur Talgatovich; Zholdoshev Saparbai Tezekbayevich; Muidinov Fazliddin Fayozidinovich

doi:10.51847/KhjrtFnxNb

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Predictors of long-term shortness of breath in COVID-19: A prospective study

Abdimomunova Begimai Toktobolotovna^*✉ , Kutmanova Ainura Zarylbekovna , Dautov Timur Talgatovich , Zholdoshev Saparbai Tezekbayevich , Muidinov Fazliddin Fayozidinovich

Abstract

Persistent symptoms after COVID-19 continue to be actively studied today due to their impact on the quality of life of patients. The symptoms of long-term COVID-19 have a wide range and require long-term monitoring, and even repeated hospitalization due to deterioration of the condition. The study aimed to determine the predictors of the persistence of prolonged shortness of breath in patients in the post-covid period and to analyze their survival. The observational, prospective multicenter cohort study included 252 hospitalized COVID-19 patients (56% women, average age 47), monitored for 48-96 weeks post-infection from 2020 to May 2022. Shortness of breath was assessed via physical activity in a subsample, with risk factors identified using chi-squared, Fisher’s exact, and Wilcoxon rank sum tests, and logistic regression for survival analysis. Long-term follow-up (48-96 weeks) of 252 acute COVID-19 patients showed that 90 patient (35.7%) retained practically all acute symptoms, although severity did not affect them. In the 90 patients, 56 (62.2%) developed chronic shortness of breath and were hospitalized again. Prolonged dyspnea in postcovid syndrome was statistically dependent on acute infection severity, neutrophil, fibrinogen, and CRP levels, and lung CT alterations. Predicting the development of dyspnea based on basic markers of inflammation and the CT picture of the lungs can be used in various settings, including the level of primary health care, which can help promote early and effective treatment‎.

Keywords: Primary health care, Shortness of breath, COVID-19, Postcovid syndrome, Quality of life

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Toktobolotovna AB, Zarylbekovna KA, Talgatovich DT, Tezekbayevich ZS, Fayozidinovich MF. Predictors of long-term shortness of breath in COVID-19: A prospective study. J Adv Pharm Educ Res. 2024;14(4):105-11. https://doi.org/10.51847/KhjrtFnxNb

APA

Toktobolotovna, A. B., Zarylbekovna, K. A., Talgatovich, D. T., Tezekbayevich, Z. S., & Fayozidinovich, M. F. (2024). Predictors of long-term shortness of breath in COVID-19: A prospective study. Journal of Advanced Pharmacy Education and Research, 14(4), 105-111. https://doi.org/10.51847/KhjrtFnxNb