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Abstract

A substantial proportion of the population in many countries has been afflicted with COVID-19 coronavirus infection, frequently accompanied by clinically significant symptoms even after the acute infection was treated. During the acute phase of COVID-19, the illness severity varied from moderate to severe, resulting in the development of widespread organ damage and subsequent multisystem symptoms of post-COVID syndrome. This prospective cohort study involved 358 patients diagnosed with COVID-19. The R-studio software was used to execute the statistical analysis, which included the computation of the p-value, median (IQR), n (%), Wilcoxon rank sum test, and Pearson's Chi-squared test.In our study The average age of COVID-19 acute patients was 56 (range: 15 to 84). Women accounted for 53.1% of cases. Cardiovascular, respiratory, and endocrine illnesses were the most common comorbidities. In the acute phase of COVID-19, fever, tiredness, and malaise were prevalent. Respiratory difficulties and cold symptoms were the main complaints. The severity of the illness was connected to lung tissue destruction in the CT picture and increases in CRP, procalcitonin, D-dimer, and fibrinogen. Polypragmasia (using five or more medicines simultaneously) with antimicrobials, GCS, and other symptomatic treatments was seen in therapeutic approaches. We also found key indicators of post-Covid syndrome, such as severe pneumonia with extensive lung damage (CT-3 and CT-4), high CRP, and self-medication with antibiotics and corticosteroids in the early stages of acute Covid-19. Our study emphasises on postcovid syndrome causes. This result corresponded with female population, having severe acute COVID-19, having a reinfection or breakthrough infection after immunisation, having other concomitant conditions, and self-medicating with various drugs‎.

Keywords: COVID-19, Pandemic, Post-COVID syndrome, Risk factors, Kyrgyz population

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