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Abstract

The purpose of the study was to evaluate the effectiveness of Nigella Sativa on tremors in patients with multiple sclerosis. 31 patients were randomly divided into two groups in a double-blind clinical trial study. The Fahn-Tolosa-Marin Tremor Rating Scale and Health Survey were used. Inclusion criteria were tremor due to MS, EDSS score between 2 and 6, having stable and regular drug treatment in the last 3 months, not using alternative drugs from 7 days before the start of the intervention until the end of the intervention, and exclusion criteria were, history of alcohol or substance use disorder, pregnancy or breastfeeding, kidney or liver dysfunction, steroid treatment during one month before the start of the study, neurological comorbidities in addition to MS, heart disease, allergy to Nigella Sativa and an attack of the disease in the last month. Analyses were performed using SPSS-22. The average age of the participants in the case group was 40.12±10.46 and in the control group were 32.26±9.26. It was showed that there is no significant relationship between the demographic data in the two groups (P-value=0.447). The statistical comparison of rest, postural, and tension tremor variables did not show a significant relationship between the two groups. The statistical analysis between the two groups showed that there was no significant relationship between quality of life questionnaires and the clinical tremor rating scale. This study showed that there were no significant differences between the case and control groups in any of the tremor characteristics‎.