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Abstract

This study explores the impact of the extract from the bursa of Fabricius on the bone marrow of mice with CPA-induced immunodeficiency. Myelogram analysis revealed that CPA administration resulted in lymphopenia and suppression of lymphopoiesis, while granulocyte sprouts are activated, indicating a non-specific immune response. The treatment of mice with CPA-induced immunodeficiency with the extract from the bursa of Fabricius stimulated the lymphoid lineage in the bone marrow, as evidenced by an increase in lymphoblasts and mature lymphocytes. However, there was no significant restoration of lymphocyte numbers in peripheral blood, possibly due to the lack of antigen stimulation. The extract also led to an increase in neutrophilic and erythroid cell content. Additionally, administration of the extract from the bursa of Fabricius stimulated cell mitotic activity and increased the total number of myelokaryocytes. These findings suggest a significant immunotropic effect of the extract on bone marrow under conditions of immunodeficiency, resulting in the activation of lymphoid and erythroid sprouts, as well as an increased leukocyte and granulocyte content. The demonstrated ability of the extract to counteract the cytostatic effect of CPA highlights the potential for further research into isolating and identifying active peptides with immunostimulatory properties‎.

Keywords: Bone marrow, Cell cycle, Immune modulation, Secondary immunodeficiencies, Myelogram

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