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Abstract

Antimicrobial resistance (AMR) has become a global health issue, with the increased use of antibiotics during the COVID-19 pandemic to minimize acute mortality potentially leading to a long-term spike in AMR fatalities. In this study, we investigated the influence of the COVID-19 pandemic on Kyrgyz antimicrobial resistance and raised awareness of the dangers of antibiotic misuse. This observational retrospective cross-sectional study investigated clinical samples for pathogenic and conditionally pathogenic microbiota. Every tenth patient was sampled, according to the Laboratory Center for Disease Prevention and State Sanitary and Epidemiological Supervision research. The isolated microorganisms were identified and antibiotic-sensitive tested on Muller-Hinton agar with nine antibacterial groups by disc diffusion. The cohort study of 419 coronavirus-infected patients found 64.4% (n = 270) positive PCR results and 35.5% (n = 149) negative results. 10.7% (n = 45) had a light infection, 17.4% (n = 73) had a moderate infection, 35.8% (n = 150) had a severe infection, and 9.5% (n = 40) had a very serious illness. The new coronavirus cases expanded rapidly, causing pneumonia and antibiotic use in most LMICs, including countries like Kyrgyzstan. Also, Ciprofloxacin, ceftriaxone, azithromycin, and levofloxacin resistance rose 30% during COVID-19. In the COVID-19 pandemic, infection prevention, rational antibiotic usage, and AMR monitoring must be strengthened‎.

Keywords: Pandemic, COVID-19, Sensitivity, Resistance, Antibacterial drugs

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