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Sahar Abdulrudha Majeed , Heider Qassam , Ammar Rasoul Mohammad , Ekhlas Sabah Hassan^*✉ , Karrar Kareem Gaen , Suhad Traiji Zamil , Suaad Traiji Zamil¬ , Hussein A Abdulkadhim

1. Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Iraq.
2. Department of Toxicology, Faculty of Pharmacy, University of Kufa, Iraq.

Abstract

Intestinal mobility disorders are either hypo or hypermotility conditions that affect the gastrointestinal tract due to smooth muscle or neuronal disorders. Betalains are good candidates to be evaluated for their intestinal modulating properties since they may have a higher safety index and pleiotropic efficacy. In this small sample, clinical trials (N = 26 cases of motility disorders), fasting, and betalains intake cases of motility disorders had been measured for their electro enterography EEnG at 8:00 am. Betalains intake cases were given oral doses of 12 mg/kg betalains extract 30 minutes before measurements. A biosignal interface was used (UNO, Italy) and the driver was installed within the Simulink R2021b block with the use of a lowpass filter to cancel ECG wave interference. The participant's privacy, autonomy, and information about the use of this habitually used beetroot extract were insured and verbally explained regarding the purpose of the study, the method, and the time of analysis. The results have clearly shown that the oral administration of the aqueous extract of betalains achieved mild antispasmodic effects in cases with intestinal hypermotility disorders by decreasing the maximum force of contraction as had been indicated by EEnG reduction in the mean amplitude difference from 1.25 micV to 1.07 micV. Moreover, betalains caused EEnG frequency to decline from 21.5 MHz to 18.5 MHz. These effects were mild although statistically significant (P = 0.04). The oral dose of 12 mg/kg of betalains aqueous extract showed mild but significant intestinal relaxing effects in patients with intestinal hypermotility disorders‎.

 

Keywords: Betalains, Electroenterography, EEnG, Motility disorders, Aqueous extract, Relaxant

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