Views: 210 Downloads: 23

Abstract

Selenium is an essential trace element that plays a key role in antioxidant protection and immune regulation. In this study, the effectiveness of a 12-week intake of selenomethionine (200 mcg /day) for the correction of selenium deficiency and related metabolic disorders was studied. A randomized, double-blind, placebo-controlled trial involved 60 volunteers with baseline plasma selenium levels <70 mcg/l. The primary criteria for evaluating the effectiveness of the intervention were the dynamics of selenium status, indicators of oxidative stress (malondialdehyde and glutathione peroxidase activity), and immunological parameters (IgA, IL-6 levels, and lymphocyte subpopulations). The results of the study showed that taking selenomethionine led to a significant increase in plasma selenium levels by 58.7% (p < 0.001), accompanied by a decrease in malondialdehyde levels by 33% and an increase in glutathione peroxidase activity by 38%. The immunological profile showed a significant increase in the level of secretory IgA (by 30%) and an increase in the number of NK cells (by 24%). A subjective assessment of the quality of life according to the SF-36 questionnaire revealed an improvement in vital signs by 25% and overall well-being by 19%. The data obtained indicate the high efficacy of selenomethionine in the correction of selenium deficiency conditions and related disorders. The results of the study substantiate the expediency of using selenium-containing additives to improve antioxidant protection and immune function, especially in residents of regions with low selenium content in food products‎.

Keywords: Selenium, Selenomethionine, Oxidative stress, Antioxidant protection, Immune status, Biologically active additives

Citation Formats: