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Marina Verevkina , Ilona Gasparian , Mikhail Ermakov , Alexey Kozlikin , Elena Pavlenko , Alexey Pavlenko^*✉ , Eduard Tikhonov , Andrey Matyukhin

1. Basic Department of Epizootiology and Microbiology, Institute of Veterinary Medicine and Biotechnology, Stavropol State Agrarian University, Stavropol, Russia.
2. Department of Therapy, Faculty of Medicine, Stavropol State Medical University, Stavropol, Russia.
3. Department of Food Technology, Faculty of Biotechnology, Don State Agrarian University, Persianovskiy, Russia.
4. Department of Chemical Technology, Machinery and Apparatus of Chemical Production Development, Nevinnomyssk Technological Institute, North Caucasus Federal University, Nevinnomyssk, Russia.
5. Department of the Territory of Advanced Socio-economic Development, Nevinnomyssk Technological Institute, North Caucasus Federal University, Nevinnomyssk, Russia.
6. Department of International Relations and Foreign Policy, Russian Institute of International Relations and Socio-Political Sciences, Moscow State Linguistic University, Moscow, Russia.
7. Department of History and Cultural Studies, Humanitarian and Applied Institute, National Research University «Moscow Power Engineering Institute», Moscow, Russia.

Abstract

The aim of this work was the fortification of milk with a bioavailable complex of iron with ascorbic acid and in vivo evaluation of its effect on the hematological parameters of laboratory rats. To do this, we produced sterilized milk with iron and ascorbic acid supplementations. Fortification of milk increased the iron content to 1.0 mg/100 mL and ascorbic acid to 3.0 mg/100 mL, which meets the requirements for iron and ascorbic acid levels in children's nutrition. An in vivo experiment was performed on 42 male rats of the Wistar line with an initial body weight of 120-240 g. As a result of the study, it was found that administration of milk fortified with iron and ascorbic acid to rats with severe anemia against the background of an iron-deficient diet at a dose of 1.7 mL per 100 g of body weight for 20 days helps to prevent the development of the condition of IDA in animals. The results of the study show the great prospects of using milk fortified with iron and ascorbic acid for the prevention of iron deficiency anemia‎.

Keywords: Fe, Vitamin C, Fortification, Hematological parameters, Biochemical parameters

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