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Abstract

Polycystic ovary syndrome (PCOS) is a  metabolic disorder and women with PCOS have a high prevalence of non-alcoholic fatty liver disease (NAFLD). Although hyperandrogenism and insulin resistance are common pathophysiologies in NAFLD and PCOS, the relationship between these two diseases is still controversial.  The present descriptive-analytical study examined patients who referred to Imam Khomeini Hospital in Ahvaz because of infertility in 2023 and the diagnosis of PCOS was confirmable based on the Rotterdam criteria. The study investigated NAFLD based on the results of liver ultrasound and liver enzyme tests, and calculated the frequency of NAFLD. 28 patients (31.11%), from among 90 women with PCOS, had NAFLD. As the results of an examination of various laboratory, clinical and metabolic parameters showed, there was a significant relationship between individuals with NAFLD and those without NAFLD in the  liver enzymes AST and ALT and BMI in women with PCOS, so that the  level of liver enzymes AST and ALT was higher in individuals with NAFLD than those without NAFLD. No significant relationship was observed in other parameters such as Cholesterol,FBS, 2hpp, blood pressure, underlying disease, FSH, LH, AMH and testosteronee,frequency of hirsutism and menses pattern  . The results of the present study reported a high prevalence of NAFLD in women with PCOS, which it is associated with the increase in the level of liver enzymes AST and ALT and it is significantly more in obese people.