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Abstract

This study was conducted to identify the proportion of antibiotic types used in treating acute exacerbations of COPD and to evaluate the treatment outcomes of antibiotic use for acute COPD exacerbations at Cho Ray Hospital in 2023. A total of 306 patients were included in the analysis. Males accounted for 88.9% of the study population. The mean age was 71.87 ± 9.91 years. Most participants were hospitalized due to moderate to severe acute COPD exacerbations (38.6% and 61.1%, respectively). Microbiological analysis showed a wide variety of common bacterial pathogens, with Pseudomonas aeruginosa and other community-acquired bacteria frequently identified. Beta-lactams and Quinolones were the most commonly used and effective antibiotics. The study results show that most COPD patients had positive treatment effects. The analysis of treatment outcomes by antibiotic groups showed significant differences in symptom improvement, unchanged status, and worsening conditions, reflecting both the effectiveness and limitations of each antibiotic group in treating acute COPD. Overall, antibiotic selection appeared appropriate, with high adherence to guidelines in mild and moderate cases and slightly lower appropriateness in severe cases. These findings highlight the importance of individualized treatment based on patient severity, microbiological results, and careful antibiotic selection to optimize outcomes.

Keywords: Antibiotic use, Acute exacerbations, COPD, Cho Ray, Hospital

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