%0 Journal Article
%T Evaluation of the neuroprotective effect of root and leaf extracts of Chlorophytum comosum       ‎
%A Elvira Yasharovna Yagubova
%A Gabidat Teymurovna Gusenova
%A Fatima Vakhayevna Zubiyeva
%A Valeriya Vitalevna Berezhnaya
%A Karina Magomednasirovna Pulatova
%A Konstantin Khadisovich Tomboidi
%A Aminat Ruslanovna Gasarova
%A Elmira Mirzemetovna Gereykhanova
%J Journal of Advanced Pharmacy Education and Research
%@ 2249-3379
%D 2023
%V 13
%N 3
%R 10.51847/W5wvQzvguf
%P 52-55
%X The aim of this study was a comparative study of the neuroprotective efficacy of root and leaf extracts of Chlorophytum comosum, as well as their combined use in glutamate excitotoxicity in a culture of rat cerebellar neurons. The effect of Chlorophytum comosum extracts on glutamate excitotoxicity was studied on 7–8 day old cultures of cerebellar neurons obtained from 7-9 day old rats by enzyme mechanical dissociation. We found that the addition of extracts of Chlorophytum comosum to the culture medium in the post-glutamate period led to a significant reduction in the death of cerebellar neurons in culture. The percentage of surviving neurons, when Chlorophytum comosum was introduced at a concentration of 60 μg/mL, ranged from 32.7 to 36.5%, and at a concentration of 90 μg/mL, from 37.8 to 42.4%. As a result of the experiment, it was concluded that root and leaf extracts of Chlorophytum comosum have a pronounced and almost equal neuroprotective effect in the case of glutamate excitotoxicity‎.
%U https://japer.in/article/evaluation-of-the-neuroprotective-effect-of-root-and-leaf-extracts-of-chlorophytum-comosum-lr-w9ynuoqhvlgmz4w