TY  - JOUR
T1  - Evaluation of the neuroprotective effect of root and leaf extracts of Chlorophytum comosum       ‎
A1  - Elvira Yasharovna Yagubova
A1  - Gabidat Teymurovna Gusenova
A1  - Fatima Vakhayevna Zubiyeva
A1  - Valeriya Vitalevna Berezhnaya
A1  - Karina Magomednasirovna Pulatova
A1  - Konstantin Khadisovich Tomboidi
A1  - Aminat Ruslanovna Gasarova
A1  - Elmira Mirzemetovna Gereykhanova
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2023
VL  - 13
IS  - 3
DO  - 10.51847/W5wvQzvguf
SP  - 52
EP  - 55
N2  - The aim of this study was a comparative study of the neuroprotective efficacy of root and leaf extracts of Chlorophytum comosum, as well as their combined use in glutamate excitotoxicity in a culture of rat cerebellar neurons. The effect of Chlorophytum comosum extracts on glutamate excitotoxicity was studied on 7–8 day old cultures of cerebellar neurons obtained from 7-9 day old rats by enzyme mechanical dissociation. We found that the addition of extracts of Chlorophytum comosum to the culture medium in the post-glutamate period led to a significant reduction in the death of cerebellar neurons in culture. The percentage of surviving neurons, when Chlorophytum comosum was introduced at a concentration of 60 μg/mL, ranged from 32.7 to 36.5%, and at a concentration of 90 μg/mL, from 37.8 to 42.4%. As a result of the experiment, it was concluded that root and leaf extracts of Chlorophytum comosum have a pronounced and almost equal neuroprotective effect in the case of glutamate excitotoxicity‎.
UR  - https://japer.in/article/evaluation-of-the-neuroprotective-effect-of-root-and-leaf-extracts-of-chlorophytum-comosum-lr-w9ynuoqhvlgmz4w
ER  -