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ACTH₄₋₁₀PRO⁸-GLY⁹-PRO¹⁰ improves Neutrophil profile in spinal cord injury of rat models ‎


Muhammad Faris , Budi Utomo , Asra Al Fauzi , I Ketut Sudiana , Sri Maliawan , Yoes Prijatna Dahlan , Oski Illiandri , Moh. Hasan Machfoed , Abdul Hafid Bajamal

Abstract

Acute spinal cord injury (SCI) is a health burden that affects daily function. Based on its prevalence, SCI becomes a major problem in the country. Inflammation is one of SCI property that stays as the main target for management in the last decade. ACTH4-10PRO8-GLY9-PRO1 (Met-Glu-His-Phe-Pro-Gly-Pro) has been known for its anti-inflammatory properties but remains unclear for SCI models. This experimental study was done on the SCI model of the Sprague-Dawley rat. Neutrophil was taken as an inflammatory marker from the spinal cord of the rat model on 3 and 6 hours of observation following injury. Statistical analysis was done using ANOVA comparison test with significance cut off of p < 0.05, CI 95%.

Six samples from each control and treatment group (normal saline 3 and 6 hours; ACTH4-10PRO8-GLY9-PRO10 3 and 6 hours) were observed for immunoreacted values of neutrophil staining to assess inflammatory reactions in spinal cord injury models. Statistical analysis continued with the Kruskal-Wallis test and found significant differences (p <0.001) between groups. Post-hoc tests were carried out using the Steel method. The most significant difference in Neutrophil levels was found in the ACTH4-10PRO8-GLY9-PRO10 6 hours group against normal saline 6 hours‎.


How to cite this article:
Vancouver
Faris M, Utomo B, Fauzi A A, Sudiana I K, Maliawan S, Dahlan Y P, et al. ACTH₄₋₁₀PRO⁸-GLY⁹-PRO¹⁰ improves Neutrophil profile in spinal cord injury of rat models ‎. J Adv Pharm Educ Res. 2021;11(2):61-5. https://doi.org/10.51847/lWGhW1Yn1Q
APA
Faris, M., Utomo, B., Fauzi, A. A., Sudiana, I. K., Maliawan, S., Dahlan, Y. P., & et al (2021). ACTH₄₋₁₀PRO⁸-GLY⁹-PRO¹⁰ improves Neutrophil profile in spinal cord injury of rat models ‎. Journal Of Advanced Pharmacy Education And Research, 11(2),61-65. https://doi.org/10.51847/lWGhW1Yn1Q
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