TY - JOUR T1 - ACTH4-10PRO8-GLY9-PRO10 improves Neutrophil profile in spinal cord injury of rat models A1 - Muhammad Faris A1 - Budi Utomo A1 - Asra Al Fauzi A1 - I Ketut Sudiana A1 - Sri Maliawan A1 - Yoes Prijatna Dahlan A1 - Oski Illiandri A1 - Moh. Hasan Machfoed A1 - Abdul Hafid Bajamal JF - Journal of Advanced Pharmacy Education and Research JO - J Adv Pharm Educ Res SN - 2249-3379 Y1 - 2021 VL - 11 IS - 2 DO - 10.51847/lWGhW1Yn1Q SP - 61 EP - 65 N2 - Acute spinal cord injury (SCI) is a health burden that affects daily function. Based on its prevalence, SCI becomes a major problem in the country. Inflammation is one of SCI property that stays as the main target for management in the last decade. ACTH4-10PRO8-GLY9-PRO1 (Met-Glu-His-Phe-Pro-Gly-Pro) has been known for its anti-inflammatory properties but remains unclear for SCI models. This experimental study was done on the SCI model of the Sprague-Dawley rat. Neutrophil was taken as an inflammatory marker from the spinal cord of the rat model on 3 and 6 hours of observation following injury. Statistical analysis was done using ANOVA comparison test with significance cut off of p < 0.05, CI 95%. Six samples from each control and treatment group (normal saline 3 and 6 hours; ACTH4-10PRO8-GLY9-PRO10 3 and 6 hours) were observed for immunoreacted values of neutrophil staining to assess inflammatory reactions in spinal cord injury models. Statistical analysis continued with the Kruskal-Wallis test and found significant differences (p UR - https://japer.in/article/acth410pro8-gly9-pro1-improves-neutrophil-profile-in-spinal-cord-injury-of-rat-models-rrxpebddtloiwkp ER -