%0 Journal Article %T ACTH4-10PRO8-GLY9-PRO10 improves Neutrophil profile in spinal cord injury of rat models %A Muhammad Faris %A Budi Utomo %A Asra Al Fauzi %A I Ketut Sudiana %A Sri Maliawan %A Yoes Prijatna Dahlan %A Oski Illiandri %A Moh. Hasan Machfoed %A Abdul Hafid Bajamal %J Journal of Advanced Pharmacy Education and Research %@ 2249-3379 %D 2021 %V 11 %N 2 %R 10.51847/lWGhW1Yn1Q %P 61-65 %X Acute spinal cord injury (SCI) is a health burden that affects daily function. Based on its prevalence, SCI becomes a major problem in the country. Inflammation is one of SCI property that stays as the main target for management in the last decade. ACTH4-10PRO8-GLY9-PRO1 (Met-Glu-His-Phe-Pro-Gly-Pro) has been known for its anti-inflammatory properties but remains unclear for SCI models. This experimental study was done on the SCI model of the Sprague-Dawley rat. Neutrophil was taken as an inflammatory marker from the spinal cord of the rat model on 3 and 6 hours of observation following injury. Statistical analysis was done using ANOVA comparison test with significance cut off of p < 0.05, CI 95%. Six samples from each control and treatment group (normal saline 3 and 6 hours; ACTH4-10PRO8-GLY9-PRO10 3 and 6 hours) were observed for immunoreacted values of neutrophil staining to assess inflammatory reactions in spinal cord injury models. Statistical analysis continued with the Kruskal-Wallis test and found significant differences (p %U https://japer.in/article/acth410pro8-gly9-pro1-improves-neutrophil-profile-in-spinal-cord-injury-of-rat-models-rrxpebddtloiwkp