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Sirih (Piper betle) folium as new candidate for anti-herpes virus: In-silico study


Resmi Mustarichie, Nyi Mekar Saptarini

Abstract

The benefits of betle leaf to treat diseases such as bad breath, cuts, inflammation, coughs, colds, digestive disorders have traditionally been known for a long time. Most of the health-related benefits of betle leaf come from the bioactive phenolic compounds found in the betle leaf, and polyphenol compounds have the potential as anti-virus. Herpes simplex virus (HSV) is a highly contagious pathogen that causes recurrent lesions. The process of herpes infection begins when the virion binds to the heparan sulfate portion present on the host cell surface. HSV is a highly contagious pathogen that causes recurrent lesions. The entry of the virus into cells by triggering the membrane lining or a combination of cells causes herpes infection. This study aims to determine the anti-herpes bioactive compounds contained in betle leaf against the HSV-1 receptor. This research used Discovery Studio for docking and ADMET methods. The computational results found that Guineensine was a bioactive compound that had activity against the HSV-1. It had a binding affinity of -9.09 Kcal/Mol and an inhibition constant of 0.217 µM that’s better than acyclovir as a comparison drug. Despite having good ADME properties, this compound could not be used for oral treatment because it was mutagenic.


How to cite this article:
Vancouver
Mustarichie R, Saptarini NM. Sirih (Piper betle) folium as new candidate for anti-herpes virus: In-silico study. J Adv Pharm Educ Res. 2023;13(1):46-50. https://doi.org/10.51847/mcuhssaHlU
APA
Mustarichie, R., & Saptarini, N. M. (2023). Sirih (Piper betle) folium as new candidate for anti-herpes virus: In-silico study. Journal of Advanced Pharmacy Education and Research, 13(1), 46-50. https://doi.org/10.51847/mcuhssaHlU
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