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Sirih (Piper betle) folium as new candidate for anti-herpes virus: In-silico study


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Abstract

The benefits of betle leaf to treat diseases such as bad breath, cuts, inflammation, coughs, colds, digestive disorders have traditionally been known for a long time. Most of the health-related benefits of betle leaf come from the bioactive phenolic compounds found in the betle leaf, and polyphenol compounds have the potential as anti-virus. Herpes simplex virus (HSV) is a highly contagious pathogen that causes recurrent lesions. The process of herpes infection begins when the virion binds to the heparan sulfate portion present on the host cell surface. HSV is a highly contagious pathogen that causes recurrent lesions. The entry of the virus into cells by triggering the membrane lining or a combination of cells causes herpes infection. This study aims to determine the anti-herpes bioactive compounds contained in betle leaf against the HSV-1 receptor. This research used Discovery Studio for docking and ADMET methods. The computational results found that Guineensine was a bioactive compound that had activity against the HSV-1. It had a binding affinity of -9.09 Kcal/Mol and an inhibition constant of 0.217 µM that’s better than acyclovir as a comparison drug. Despite having good ADME properties, this compound could not be used for oral treatment because it was mutagenic.


How to cite this article:
Vancouver
Mustarichie R, Saptarini NM. Sirih (Piper betle) folium as new candidate for anti-herpes virus: In-silico study. J Adv Pharm Educ Res. 2023;13(1):46-50. https://doi.org/10.51847/mcuhssaHlU
APA
Mustarichie, R., & Saptarini, N. M. (2023). Sirih (Piper betle) folium as new candidate for anti-herpes virus: In-silico study. Journal of Advanced Pharmacy Education and Research, 13(1), 46-50. https://doi.org/10.51847/mcuhssaHlU
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