%0 Journal Article
%T Sirih (Piper betle) folium as new candidate for anti-herpes virus: In-silico study
%A Resmi Mustarichie
%A Nyi Mekar Saptarini
%J Journal of Advanced Pharmacy Education and Research
%@ 2249-3379
%D 2023
%V 13
%N 1
%R 10.51847/mcuhssaHlU
%P 46-50
%X The benefits of betle leaf to treat diseases such as bad breath, cuts, inflammation, coughs, colds, digestive disorders have traditionally been known for a long time. Most of the health-related benefits of betle leaf come from the bioactive phenolic compounds found in the betle leaf, and polyphenol compounds have the potential as anti-virus. Herpes simplex virus (HSV) is a highly contagious pathogen that causes recurrent lesions. The process of herpes infection begins when the virion binds to the heparan sulfate portion present on the host cell surface. HSV is a highly contagious pathogen that causes recurrent lesions. The entry of the virus into cells by triggering the membrane lining or a combination of cells causes herpes infection. This study aims to determine the anti-herpes bioactive compounds contained in betle leaf against the HSV-1 receptor. This research used Discovery Studio for docking and ADMET methods. The computational results found that Guineensine was a bioactive compound that had activity against the HSV-1. It had a binding affinity of -9.09 Kcal/Mol and an inhibition constant of 0.217 µM that’s better than acyclovir as a comparison drug. Despite having good ADME properties, this compound could not be used for oral treatment because it was mutagenic‎.
%U https://japer.in/article/sirih-piper-betle-folium-as-new-candidate-for-anti-herpes-virus-in-silico-study-o6i1esurpzgb2dq