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Aida Batrazovna Badrieva , Gerontiy Giviyevich Bichenov , Zarita Ahmetovna Haluhoeva , Aina Ayupovna Arapieva , Rasul Musaevitch Baykhanov , Zaira Nadirovna Khalibekova , Pyatimat Magomedbashirovna Mattcieva , Albina Sergeevna Salimova

Abstract

Basic pharmacotherapy of cerebral ischemia includes the use of vasoactive, antiplatelet, nootropic, neuroprotective drugs, antihypoxants, and antioxidants. However, despite their sufficiently high efficiency, their combined use often leads to the development of undesirable reactions. The work aimed to conduct a morphometric study of neurons of the frontal lobe of the brain and the CA1 region of the hippocampus of rats with simulated total ischemia of the brain and correction with an aqueous extract of Chlorophytum comosum. In a statistical study, it was found that ischemic damage to neurons of both the frontal lobe and the hippocampus was significantly more pronounced in the group with a 4-vessel model of brain ischemia without correction with an aqueous extract of Chlorophytum comosum. The minimum diameter, perimeter, and area of neurons, diameter, perimeter, and area of nuclei were significantly different (p<0.05). The number of bicellular neurons was significantly greater when corrected with an aqueous extract of Chlorophytum comosum (p<0.05), which reflects the functional state of neurons, their greater activity, and their ability to regenerate and reparative processes. No significant differences were found when measuring the maximum diameter of the neuronal nuclei (p>0.05). Correction of ischemic damage with an aqueous extract of Chlorophytum comosum showed a statistically significant increase in the resistance of neurons of the frontal lobe and CA1 region of the hippocampus to hypoxia and ischemia, a significant decrease in the number of dead neurons and greater activity of reparative processes‎.

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