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Dian Eka Ermawati , Indah Ayu Saputri , Muhammad Fiqri Zulpadly , Mukaromah Nur Dewi Kartikasari

Abstract

A Moringa leaves ethanolic extract at a dose of 5%-15% are recommended as an anti-inflammatory agent for topical preparations. A transdermal patch has several advantages, such as ease of application, painlessness, and long-lasting action. Polymer is the most important component in patch performance, and it can be determined using a release and permeation study. This study used a combination polymer of Polyvinyl Alcohol (PVA) and Alpha-cellulose to produce a faster drug release profile. Therefore, this study aimed to determine the permeation profile of flavonoid total from the patch. A flavonoid total model from Moringa leaves ethanolic extract was used, and patches were formulated from a combination of PVA and Alpha-cellulose with a ratio of 1: 2. Subsequently, the patch was evaluated for flavonoid total permeation study using a modified vertical type of Franz diffusion cell equipped with chicken's egg cell membrane. The flavonoid total released from the patch was 26.16% for 5 hours with a diffusion mechanism. Furthermore, the weight of the total flavonoid that was transported through the chicken's egg cell membrane was 104.23 μg for 5 hours. The penetration flux value was 3.27x10^-6 mg.sec^-1.cm^-2 and the membrane permeability value was 2.46x10^-6 cm/sec. The results showed that the Moringa patch can be developed as a topical anti-inflammatory preparation‎.

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