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Permeation studies of flavonoid total on Moringa leaves ethanolic extract patch

Dian Eka Ermawati, Indah Ayu Saputri, Muhammad Fiqri Zulpadly, Mukaromah Nur Dewi Kartikasari


A Moringa leaves ethanolic extract at a dose of 5%-15% are recommended as an anti-inflammatory agent for topical preparations. A transdermal patch has several advantages, such as ease of application, painlessness, and long-lasting action. Polymer is the most important component in patch performance, and it can be determined using a release and permeation study. This study used a combination polymer of Polyvinyl Alcohol (PVA) and Alpha-cellulose to produce a faster drug release profile. Therefore, this study aimed to determine the permeation profile of flavonoid total from the patch. A flavonoid total model from Moringa leaves ethanolic extract was used, and patches were formulated from a combination of PVA and Alpha-cellulose with a ratio of 1: 2. Subsequently, the patch was evaluated for flavonoid total permeation study using a modified vertical type of Franz diffusion cell equipped with chicken's egg cell membrane. The flavonoid total released from the patch was 26.16% for 5 hours with a diffusion mechanism. Furthermore, the weight of the total flavonoid that was transported through the chicken's egg cell membrane was 104.23 μg for 5 hours. The penetration flux value was 3.27x10-6 mg.sec-1.cm-2 and the membrane permeability value was 2.46x10-6 cm/sec. The results showed that the Moringa patch can be developed as a topical anti-inflammatory preparation.

How to cite this article:
Ermawati DE, Saputri IA, Zulpadly MF, Kartikasari MND. Permeation studies of flavonoid total on Moringa leaves ethanolic extract patch. J Adv Pharm Educ Res. 2023;13(4):1-7. https://doi.org/10.51847/t6FBe7onUl
Ermawati, D. E., Saputri, I. A., Zulpadly, M. F., & Kartikasari, M. N. D. (2023). Permeation studies of flavonoid total on Moringa leaves ethanolic extract patch. Journal of Advanced Pharmacy Education and Research, 13(4), 1-7. https://doi.org/10.51847/t6FBe7onUl
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