TY  - JOUR
T1  - Permeation studies of flavonoid total on Moringa leaves ethanolic extract patch       ‎
A1  - Dian Eka Ermawati
A1  - Indah Ayu Saputri
A1  - Muhammad Fiqri Zulpadly
A1  - Mukaromah Nur Dewi Kartikasari
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2023
VL  - 13
IS  - 4
DO  - 10.51847/t6FBe7onUl
SP  - 1
EP  - 7
N2  - A Moringa leaves ethanolic extract at a dose of 5%-15% are recommended as an anti-inflammatory agent for topical preparations. A transdermal patch has several advantages, such as ease of application, painlessness, and long-lasting action. Polymer is the most important component in patch performance, and it can be determined using a release and permeation study. This study used a combination polymer of Polyvinyl Alcohol (PVA) and Alpha-cellulose to produce a faster drug release profile. Therefore, this study aimed to determine the permeation profile of flavonoid total from the patch. A flavonoid total model from Moringa leaves ethanolic extract was used, and patches were formulated from a combination of PVA and Alpha-cellulose with a ratio of 1: 2. Subsequently, the patch was evaluated for flavonoid total permeation study using a modified vertical type of Franz diffusion cell equipped with chicken's egg cell membrane. The flavonoid total released from the patch was 26.16% for 5 hours with a diffusion mechanism. Furthermore, the weight of the total flavonoid that was transported through the chicken's egg cell membrane was 104.23 μg for 5 hours. The penetration flux value was 3.27x10-6 mg.sec-1.cm-2 and the membrane permeability value was 2.46x10-6 cm/sec. The results showed that the Moringa patch can be developed as a topical anti-inflammatory preparation‎.
UR  - https://japer.in/article/permeation-studies-of-flavonoid-total-on-moringa-leaves-ethanolic-extract-patch-lrm-f5y8do5ttpvtzen
ER  -