PatiNikunja Basini, Dey Biplab Kr., Das Sudip, Sahoo Subhas

Abstract

The purpose of this review is to explore the difficulties in penetration of drug across nail plate & enhancement of bioavailability of antifungal drug. The existing clinical evidence suggests that a key to successful treatment of fungal diseases by topical antifungal product lies in ineffectively overcoming the nail barrier. Current topical treatments have limited therapeutic effectiveness possibly because they cannot sufficiently penetrate in the nail plate to transport a therapeutically sufficient quantity of antifungal drug to the target sites to eradicate the protection. Also the analysis of the drug's penetration is a difficult task. Here in the present article a method to analyze the drug permeated across nail barrier is suggested.