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Morphological and biochemical analysis of 3D scaffold based on biocompatible polymer for tissue engineering


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Abstract

In modern clinical practice, cell therapy is actively used for the treatment of degenerative diseases and malformations, burns, and injuries, as well as during dental and cosmetic operations. Thus, an urgent task is the development of new materials for tissue engineering, which implies, among other things, the study of the interaction of human cells with a three-dimensional synthetic matrix during the formation of tissues. In this scientific work, the regularities of attachment and proliferation of HeLa cells in the polymer of lactic and glycolic acids are evaluated, and some parameters reflecting the state of cells in the polymer and the development of oxidative stress in them are evaluated. It was found that the stereo ultrastructural organization of cells grown in the matrix did not differ from cells grown in vials; the dynamics of cell growth were close to the growth rate under standard conditions in vials; HeLa cells were not exposed to stress in the matrix during the entire cultivation period, which was confirmed by a stable level of intracellular glutathione and the absence of an antioxidant effect.


How to cite this article:
Vancouver
Sakhnenkova TI, Abdul-Kadyrova LR, Akhilgova ZA, Brovikova AA, Markov OO, Saribekyan AA, et al. Morphological and biochemical analysis of 3D scaffold based on biocompatible polymer for tissue engineering. J Adv Pharm Educ Res. 2023;13(3):29-33. https://doi.org/10.51847/v8o0GbXJdN
APA
Sakhnenkova, T. I., Abdul-Kadyrova, L. R., Akhilgova, Z. A., Brovikova, A. A., Markov, O. O., Saribekyan, A. A., Sampiev, R. M., & Loginov, A. A. (2023). Morphological and biochemical analysis of 3D scaffold based on biocompatible polymer for tissue engineering. Journal of Advanced Pharmacy Education and Research, 13(3), 29-33. https://doi.org/10.51847/v8o0GbXJdN
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