TY  - JOUR
T1  - Morphological and biochemical analysis of 3D scaffold based on biocompatible polymer for tissue engineering
A1  - Tatyana Ivanovna Sakhnenkova
A1  - Linda Ruslanovna Abdul-Kadyrova
A1  - Zara Alaudinovna Akhilgova
A1  - Aleksandra Andreevna Brovikova
A1  - Oleg Olegovich Markov
A1  - Anzhelika Arutyunovna Saribekyan
A1  - Rustam Magometovich Sampiev
A1  - Anton Andreevich Loginov
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2023
VL  - 13
IS  - 3
DO  - 10.51847/v8o0GbXJdN
SP  - 29
EP  - 33
N2  - In modern clinical practice, cell therapy is actively used for the treatment of degenerative diseases and malformations, burns, and injuries, as well as during dental and cosmetic operations. Thus, an urgent task is the development of new materials for tissue engineering, which implies, among other things, the study of the interaction of human cells with a three-dimensional synthetic matrix during the formation of tissues. In this scientific work, the regularities of attachment and proliferation of HeLa cells in the polymer of lactic and glycolic acids are evaluated, and some parameters reflecting the state of cells in the polymer and the development of oxidative stress in them are evaluated. It was found that the stereo ultrastructural organization of cells grown in the matrix did not differ from cells grown in vials; the dynamics of cell growth were close to the growth rate under standard conditions in vials; HeLa cells were not exposed to stress in the matrix during the entire cultivation period, which was confirmed by a stable level of intracellular glutathione and the absence of an antioxidant effect‎.
UR  - https://japer.in/article/morphological-and-biochemical-analysis-of-3d-scaffold-based-on-biocompatible-polymer-for-tissue-engi-xydj1qylerqtgxx
ER  -