Hypolipidemic activity of Ceciwis ethanol extract on wistar rats induced by high fat in vivo
Abstract
In Indonesia, cruciferous cabbage is known as Ceciwis (Brassica oleracea L. var. capitata f. alba Alef), a vegetable that can be consumed as a diet from Tegal is one of the plants rich in flavonoids and phenol proposed has an antidyslipidemic ac-tivity. The purpose of this study is to see how Ceciwis affect the lipid profile of Wistar rats (Rattus norvegicus) fed a high-fat diet. Method: Rats divided into seven groups: the normal group, the negative group, positive group, and the treatment group with several doses of ethanol extract Brassica oleracea L. var. capitata f. alba Alef (EEB) 125, 250, 500, and 1000mg/KgBW. Each test group was given a high-fat diet of egg yolk 2 times a day 2 mL/200g (p.o), as well as PTU (Propylthiouracil) 0.01% during the 2-week induction period, then for 2 weeks the extract was dosed and took cholesterol measurements to determine the lipid profile with parameters of total cholesterol (TC), low density lipoprotein (LDL), and tryglyceride (TG). Results: EEB activity at a dose of 1000mg/KgBW significantly <0.05 decreased lipid profiles for TC, LDL, and TG almost equiva-lent to simvastatin positive control. Conclusion: EEB at a dose of 1000 mg/KW containing flavonoids and phenols significantly reduced the TC, LDL, and TG profiles.
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