× Copyright Disclaimer Privacy Policy Author Guidelines Current Issue Archive Publishing Ethics Join As Reviewer Advertise Submit Article Abstracting And Indexing Editorial Board Contact Editor-in-Chief Scope of the Journal About the Journal


JAPER is indexed in SCOPUS

Views: 34 Downloads: 12

Hypolipidemic activity of Ceciwis ethanol extract on wistar rats induced by high fat in vivo


Heru Nurcahyo, Aldi Budi Riyanta, Rizki Febriyanti, Heri Sutanto, Wiwin Herdwiani

Abstract

In Indonesia, cruciferous cabbage is known as Ceciwis (Brassica oleracea L. var. capitata f. alba Alef), a vegetable that can be consumed as a diet from Tegal is one of the plants rich in flavonoids and phenol proposed has an antidyslipidemic ac-tivity. The purpose of this study is to see how Ceciwis affect the lipid profile of Wistar rats (Rattus norvegicus) fed a high-fat diet. Method: Rats divided into seven groups: the normal group, the negative group, positive group, and the treatment group with several doses of ethanol extract Brassica oleracea L. var. capitata f. alba Alef (EEB) 125, 250, 500, and 1000mg/KgBW. Each test group was given a high-fat diet of egg yolk 2 times a day 2 mL/200g (p.o), as well as PTU (Propylthiouracil) 0.01% during the 2-week induction period, then for 2 weeks the extract was dosed and took cholesterol measurements to determine the lipid profile with parameters of total cholesterol (TC), low density lipoprotein (LDL), and tryglyceride (TG). Results: EEB activity at a dose of 1000mg/KgBW significantly <0.05 decreased lipid profiles for TC, LDL, and TG almost equiva-lent to simvastatin positive control. Conclusion: EEB at a dose of 1000 mg/KW containing flavonoids and phenols significantly reduced the TC, LDL, and TG profiles.


How to cite this article:
Vancouver
Nurcahyo H, Riyanta AB, Febriyanti R, Sutanto H, Herdwiani W. Hypolipidemic activity of Ceciwis ethanol extract on wistar rats induced by high fat in vivo. J Adv Pharm Educ Res. 2023;13(1):100-4. https://doi.org/10.51847/enXiIQzXM1
APA
Nurcahyo, H., Riyanta, A. B., Febriyanti, R., Sutanto, H., & Herdwiani, W. (2023). Hypolipidemic activity of Ceciwis ethanol extract on wistar rats induced by high fat in vivo. Journal of Advanced Pharmacy Education and Research, 13(1), 100-104. https://doi.org/10.51847/enXiIQzXM1
Citation Formats:


Contact SPER Publications


SPER Publications and Solutions Pvt. Ltd.

HD - 236,
Near The Shri Ram Millenium School,
Sector 135,
Noida-Greater Noida Expressway,
Noida-201301 [Delhi-NCR] India