Nur Atik, Muhamad Arif Rachman Sururi, Raden Angga Kartiwa

Abstract

Corneal stromal wound healing is slower than other connective tissues, which is thought to be partly controlled by various matrix metalloproteinases. Transforming Growth Factors – βeta 1 (TGF-β1) appears in the three main phases of the wound healing process as a mediator and plays a role in the final matrix formation phase. Aloe vera has a glucomannan component, which can accelerate the production of TGF-β. This study aimed to compare the expression of TGF-β in corneal lamellar lacerations in mice treated with and without Aloe vera gel therapy. This was an experimental study using a mice model treated with a corneal laceration wound. The sample size obtained was 20 samples, which were grouped into four types of treatment. TGF-β1 immunohistochemistry expression on the first day in the strong positive category showed 10% without gel and 50% with gel. In contrast, the same category on the third day showed 10% without gel and 90% with gel. There were two significant differences upon these two days (p = 0.013, p = 0.003). Apart from the two groups treated with Aloe vera gel, the results were then compared between the first and third days (p = 0.141) and determined the expression of TGF-β1 on wound healing time. Assessment of TGF-β1 expression in the healing process of laceration in mice subjected to Aloe vera gel showed higher results.

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