Nur Atik , Muhamad Arif Rachman Sururi , Raden Angga Kartiwa

Abstract

Corneal stromal wound healing is slower than other connective tissues, which is thought to be partly controlled by various matrix metalloproteinases. Transforming Growth Factors – βeta 1 (TGF-β1) appears in the three main phases of the wound healing process as a mediator and plays a role in the final matrix formation phase. Aloe vera has a glucomannan component, which can accelerate the production of TGF-β. This study aimed to compare the expression of TGF-β in corneal lamellar lacerations in mice treated with and without Aloe vera gel therapy. This was an experimental study using a mice model treated with a corneal laceration wound. The sample size obtained was 20 samples, which were grouped into four types of treatment. TGF-β1 immunohistochemistry expression on the first day in the strong positive category showed 10% without gel and 50% with gel. In contrast, the same category on the third day showed 10% without gel and 90% with gel. There were two significant differences upon these two days (p = 0.013, p = 0.003). Apart from the two groups treated with Aloe vera gel, the results were then compared between the first and third days (p = 0.141) and determined the expression of TGF-β1 on wound healing time. Assessment of TGF-β1 expression in the healing process of laceration in mice subjected to Aloe vera gel showed higher results.

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