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Clinical pharmacist intervention in Appendectomy - Dexmedetomidine as an adjunct therapy

Bushra Abdel-Hadi, Sami Raid Abdel-Fattah


This research was performed by a clinical pharmacist to determine the efficacy of dexmedetomidine as an alternative therapy in laparoscopic appendectomy surgery for acute and short-lived analgesic appendicitis and to focus on the consistency of pharmacotherapy and patient safety. A randomized, double-blind, prospective analysis of 2 groups allocated to the fentanyl [GF] and fentanyl dexmedetomidine [GF-D] groups. Propofol, Sevoflurane, Atracurium, and intraoperative fentanyl bolus were administered to the patient, followed by an infusion of maintenance dose of 0.2 μg/kg/h for the two grades. GF patients were given placebo, however, while patients with GF-D received both dexmedetomidine and fentanyl as an infusion (0.5 μg/kg/h).

The requirements for postoperative analgesics and the need for initial postoperative analgesics, consistency of hemodynamic parameters, side effects of nausea and vomiting, and food tolerance have been controlled. GF-D showed lower side effects and food resistance compared to GF: pain score, morphine consumption, nausea, and vomiting (p<0.05), When GF was compared to GF-D, the period for the first postoperative morphine was shorter in GF (p<0.05). The addition of dexmedetomidine to appendectomy surgery is strongly recommended; clinical pharmacist involvement has improved patient safety and avoids any adverse drug reaction.

How to cite this article:
Abdel-Hadi B, Abdel-Fattah SR. Clinical pharmacist intervention in Appendectomy - Dexmedetomidine as an adjunct therapy. J Adv Pharm Educ Res. 2022;12(2):1-5. https://doi.org/10.51847/AYOZXtLMrj
Abdel-Hadi, B., & Abdel-Fattah, S. R. (2022). Clinical pharmacist intervention in Appendectomy - Dexmedetomidine as an adjunct therapy. Journal of Advanced Pharmacy Education and Research, 12(2), 1-5. https://doi.org/10.51847/AYOZXtLMrj
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