× About the Journal Scope of the Journal Contact Editor-in-Chief Editorial Board Current Issue Archive Abstracting And Indexing Submit Article Advertise Join As Reviewer Publishing Ethics

JAPER is indexed in SCOPUS

The effect of low frequency neuromuscular stimulation on sympathetic activity in ‎advanced heart failure‎

Donia M Elmasry , Nesreen G. Elnahas , Hazem Khorshid , Awny F Rahmy


Aim of the study: The study was designed to determine the effect of low-frequency neuromuscular stimulation on sympathetic activity in advanced heart failure. Patients and methods: In this study, thirty patients with advanced heart failure (NYHA class IV) and mean± SD age of 56.13±1.13 years were included. They received 8 weeks (4 times/week) of increasing amplitude low-frequency neuromuscular stimulation on calf and quadriceps muscles after a thorough assessment of ejection fraction, Norepinephrine levels, 6-min walk test, and assessment of disability via Minnesota Living with Heart Failure Questionnaire. Results: Statistically significant decline was observed in sympathetic activity by Norepinephrine levels associated with decreased disability, with an improvement in ejection fraction, the change percentage in ejection fraction was 3.64% (p=0.018), with a decline in norepinephrine by a change percentage of -9.28% (p<0.001), associated with an improvement in six-minute walking test by a percentage of 22.97% (p<0.001) and improved psychological, emotional, and functional status of the patients with a decline of Minnesota Living with Heart Failure Questionnaire score by -24.06% (p<0.001). Conclusion: Low-frequency neuromuscular stimulation altered sympathetic activity leading to higher functional levels.

Contact SPER Publications

SPER Publications and Solutions Pvt. Ltd.

HD - 236,
Near The Shri Ram Millenium School,
Sector 135,
Noida-Greater Noida Expressway,
Noida-201301 [Delhi-NCR] India