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Formulation and Evaluation of Mucoadhesive Microspheres of Ciprofloxacin


Shiv Shankar Hardenia , Ankit Jain1 , Ritesh Patel1 , Anu Kaushal

Abstract

In the present research work, ethylcellulose microspheres containing ciprofloxacin were prepared and evaluated for in-vitro performance of ciprofloxacin. Ciprofloxacin microspheres containing ethylcellulose were prepared by emulsion solvent diffusion evaporation method. The surface morphological characteristics of ethylcellulose microspheres were investigated using scanning electron microscopy. The polymer ratio, stirring speed and the temperature affected the particle size, shape and surface morphology of the microspheres. The in-vitro drug release was carried out using USP paddle type dissolution rate test apparatus in 0.1N Hcl dissolution medium at 291nm. It was found that drug release from the formulations was different at different concentrations of polymers and different RPM and temperature. The best cumulative release was achieved after 24 hrs i.e. 91.6%. The Mucoadhesive property of the ethylcellulose microspheres was evaluated by in-vitro wash off test. The microspheres exhibited 75% mucoadhesion and showed good drug entrapment efficiency. By, above results it was concluded that ethylcellulose microspheres showed reproducible results, with good Mucoadhesive properties and good surface morphology.



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