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Development of metoclopramide hydrochloride orodispersibal tablets using taste masking tulsion 339


Vinod M Thakare , Umesh T Jadhao , Bharat W Tekade , Kundan P Chaudhari , Piyush N Mahajan

Abstract

In the present work, orodispersible tablets of Metoclopramide HCl were prepared by direct compression techniques using complex of drug with various superdisintegrant. Before formulation of tablets, the best superdisintegrant among Tulsion 339, Ac-Di-Sol, and Sodium starch glycolate was formulated with drug and tested. For taste masking ion exchange resin Tulsion 339 Drug: Tulsion339, 1:2.25 ratios was used. The blends were examined for precompression parameters. The result were complies with Pharmacopeial and non official limits. The prepared batches of tablets were evaluated for post compression parameters. Formulations were tested for in vitro drug release pattern (in pH 6.8 buffer), Batch F5 containing Tulsion 339 showed better disintegrating character along with the immediate release (100.32% within 6 minutes). Optimized batch F5 and tablets containing different concentration of Tulsion were compared with available marketed commercial formulation.



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