× About the Journal Scope of the Journal Contact Editor-in-Chief Editorial Board Current Issue Archives Abstracting And Indexing Submit Article Advertise Join As Reviewer Publishing Ethics


JAPER is indexed in SCOPUS

Designing and Evaluation of Mucoadhesive Buccal Films of Propranolol Hydrochloride


Amit Chaudhary , Upendra Nagaich , Bhavya Rastogi

Abstract

Mucoadhesive buccal films of propranolol hydrochloride were prepared by solvent casting technique using hydroxypropyl methylcellulose (HPMC), hydroxy ethyl cellulose (HEC), sodium carboxymethyl cellulose (SCMC), polyvinyl pyrrolidone K-30 (PVP) and polyvinyl alcohol (PVA) in various proportions and combinations. Prepared films were evaluated for their weight, thickness uniformity, surface pH, swelling index, folding endurance, in-vitro residence time, in-vitro release and drug content uniformity. Ex-vivo permeation studies through the porcine buccal mucosa were performed on the selected formulations. Films exhibited sustained release over more than 6 h. The drug release from the films followed the zero order kinetics with matrix diffusion mechanism. From this study it is concluded that the films containing 20 mg propranolol hydrochloride in PVA: PVP (5 % w/v) in a 4:1 ratio (Formulation F16), showed moderate swelling, a convenient residence time and promising drug release.



DOWNLOAD


Contact SPER Publications


SPER Publications and Solutions Pvt. Ltd.

HD - 236,
Near The Shri Ram Millenium School,
Sector 135,
Noida-Greater Noida Expressway,
Noida-201301 [Delhi-NCR] India