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Comparative and Optimization of administration of Dexlansorazole through nasogastric tubes using an oral liquid vehicle as a suspending agent


Pavan Kumar Potturi1 , Yajamans Sudhakar

Abstract

Proton pump inhibitors (PPIs) are widely used for the treatment of various acidrelated disorders. For intensive care patients Stress-induced gastrointestinal tract bleeding (SGIB) is common, Dexlansoprazole is a PPI that suppresses gastric acid secretion by specific inhibition of the (H+,K+)-ATPase in the gastric parietal cell. The aim of this study was to compare the behavior of the dexlansoprazole during the transit of the pellets through the nasogastric tube and to optimize the mode of administration. In this experiment we designed to study the influence of four variables: the tube material (silicone or polyurethane), the solvent used to disperse the pellets (water or apple juice), the mode of administration and the rinse volume . We counted the pellets before administration to tube and at the tube outlet, and assayed the dexlansoprazole by UV spectrometry. The assay showed that transit of dexlansoprazole through the tube, was nearly 85.5 to 99.6%. There is asignificant improvement was obtained by the variables ‘diluent’ and ‘mode of administration’. The variable ‘rinse’ had a significant influence. Dexlansoprazole is thus the choice of Proton pump inhibitor for the treatment of patients by nasogastric tube, using a polyurethane tube and a rinse 10 ml of apple juice.



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