A Review on 1, 2, 4 - Triazoles
The 1, 2, 4-triazole ring is an ubiquitous structural feature of many synthetic compounds with diversified therapeutic efficacy. A huge volume of published literature over the last few decades precludes a comprehensive review. In this review, we have tried to figure out some of the advancement during the last few decades in medicinal chemistry of triazole derivatives with some examples of rational design as anti-fungal, anti-neoplastic, antibacterial agents etc. An emphasis has been given to structure-activity relationship, biological activity and design strategy of various mono as well as poly substituted triazoles to ensure the acceptance level of this heterocyclic ring in the field of medicinal chemistry.
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