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Abstract

Introduction: Trophoblast invasion into the decidual and decidual vessels is vital for placentation. Placental deficiencies relate to preeclampsia, fetal growth restriction (FGR) and small for gestational age (SGA) neonates. Prediction of major vascular events during pregnancy is feasible through uterine artery Doppler. The current study aimed to assess uterine artery Doppler disorder and its association with demographic characteristics of patients referring for first trimester screening.

 

Materials and Methods: The study population encompassed pregnant women referring for first trimester screening to Imam Khomeini Hospital in Ahvaz. To gather data, patients first completed a checklist, then underwent sonography and nuchal translucency (NT) thickness was determined. Subsequently, bilateral uterine artery Doppler was measured and recorded in the checklist.

 

Results: In this study, the mean uterine artery pulsatility index (PI) in the first trimester was 1.61. The mean age was 30.45 years with a standard deviation of 6.03, the mean weight was 71.15 kg with a standard deviation of 60.3, the mean height was 1.62 with a standard deviation of 0.07. Furthermore, the mean BMI was 27.04 with a standard deviation of 10.43. In the current study, in terms of determining obstetric history in patients referring for first trimester screening, primigravida had the highest frequency with 108 cases (36 percent). In the present study, no significant association was observed between uterine artery Doppler disorder and pregnancy outcomes including preterm delivery and IUGR (p>0.05), however a significant association was seen between uterine artery Doppler disorder and IVF (p=0.001).

 

Conclusion: In this study, no significant association was found between uterine artery Doppler examination in the first trimester and demographic characteristics of the patients,but this issue does not diminish the value of uterine artery examination ,and it seems that it is better to perform uterine artery doppler examination in the second trimester. yet a significant association was observed between uterine artery Doppler disorder and IVF. This indicates that uterine artery Doppler can be effective in predicting different pregnancy outcomes in the first trimester. Further adequate prospective studies utilizing standardized methods are required in the future to evaluate parameter selection and strategies for an associative aim to attain optimal prediction modalities. Advancing the knowledge of pathogenesis of complications during pregnancy facilitates the development of novel predictive and preventive modalities.